Professor Oak (anime)/History/Best Wishes series

Professor Oak was given a major redesign in the Best Wishes series, using a different shirt collar style and wearing his lab coat above it. His hairstyle also changed, becoming more boxy. These changes make his look closely resemble his most recent game counterpart artwork.

Oak made plans to travel to the Unova region to meet with his friend, Professor Juniper, in In The Shadow of Zekrom! and invited and  to go with him. He has since returned to Kanto as seen in Crisis from the Underground Up! where Ash calls his laboratory from Nimbasa City.

In New Places... Familiar Faces!, Ash called Professor Oak to inform about his loss at the Vertress Conference. In The Fires of a Red-Hot Reunion!, the Professor appeared again in a video lecture about the Kanto starter Pokémon that was presented at the Kanto Fair, accompanied by Tracey. Later, Ash's Charizard came to his lab from the Charicific Valley so Ash would switch him for his Unfezant. Oak liked the idea of Unfezant being with him, as she could make good friends with Ash's Noctowl and Staraptor.

In To Catch a Rotom!, he appeared in the Decolore Islands, having traveled to Torom Island. Professor Oak wished to capture a to study, and eventually succeeded after helping Ash and  defeat.

As seen in Butterfree and Me!, Professor Juniper sent Ash's Pokémon caught in Unova to Oak's laboratory; Ash contacted Oak to get Leavanny sent to him to help a Caterpie evolve.

In The Dream Continues! Professor Oak was interviewed by Alexa, a reporter from the Kalos region which gave him a chance to see Pokémon from there much to his delight. He was later present when Ash announced his intention to return with Alexa to Kalos to challenge its league. As usual, Professor Oak was entrusted with the care of the Pokémon Ash had caught in Unova, as well as Charizard who would be remaining at the lab permanently from then on.