Kanto Route 4/Manga/Pokémon Adventures

Route 4 appeared in Gyarados Splashes In! and Raging Rhydon. After helping Misty to recapture her rampaging Gyarados, made a phone call to  from a nearby Pokémon Center. He told Red that what had happened with Gyarados was likely caused by Team Rocket. Afterwards, Red and Misty headed to Mt. Moon in search for a Moon Stone.

After encountering Team Rocket inside the caves of Mt. Moon, Red and Misty exited the mountain on the eastern section of Route 4. Misty was frustrated for them failing to find a Moon Stone, until Red revealed that he had actually managed to find one when Pika had collapsed a part of the cave to prevent Team Rocket from following them.