Jessie/Games

Both Jessie and James appear in as in-game bosses, collectively referred to as the  Trainer class rather than by name. They first attack the undefined in Mt. Moon while trying to take one of the rare Fossils uncovered there.

Later, in Celadon City's Rocket Hideout, Jessie and James guard Giovanni's room. During that time, as the player runs into them, they are eager for revenge after busted up their plans at Mt. Moon.

They hold Mr. Fuji hostage at Pokémon Tower, attacking the player on the seventh floor.

Finally, at Silph Co. in Saffron City, Jessie and James make their final appearance, once again trying to stall the main character from reaching their Boss.

Unlike in the anime, Jessie and James do not follow the main character around and come up with their usual evil plans to capture.

Jessie and James appear in Let's Go on the same level as admins. They are more difficult than other Team Rocket grunts and will only challenge the player to a double battle. If the player tries to leave Viridian City without delivering Oak's Package, they will be blocking the north exit to the city. Above the entrance to Mount Moon, Meowth is sleeping but when the player a few steps into the cave, Team Rocket will appear, Meowth will wake up and join them (it can't speak) and they will run away so the player has to follow them in Mount Moon. When the player gets a fossil and starts leaving the cave, Jessie and James will challenge the player to a battle.