Kanto Route 16/Manga/Pokémon Adventures

Route 16 first appeared in Tauros the Tyrant, where Team Rocket attacked there, trying to get back a  she had stolen from them, which contained vital information about, required to track down the elusive Pokémon. In the end, Green managed to trick Team Rocket by having her Ditty into a copy of Team Rocket's  and having it then command Team Rocket's other Pokémon to attack their Trainers, making her getaway in the confusion.

The route appeared again in The Jynx Jinx. After Green and had managed to track down Mew with Green's Silph Scope, Team Rocket showed up in order to catch Mew for themselves. However, thanks to Red distracting Team Rocket with Poli, Mew was able to counterattack and knock out the evil team members and their before escaping. This didn't bother Green, however, as she had managed to catch a valuable photo of Mew during the incident.

The route appeared once more in A Tale of Ninetales. While leaving Celadon City, Red bumped into, who was chasing his recently obtained and still untamed , causing both Trainers to drop their Poké Balls. Later, when Red tried to save two women from a group of rampaging wild Pokémon, he found out that had been swapped out with Blue's during the earlier confusion. During the time Red spent with, he only managed to catch two new Pokémon: a and a. He later re-encountered Blue when he was trying to catch a wild with Pika. When Red sent out Blue's to defend himself from Ninetales's attacks, the Superpower Pokémon suddenly evolved into a, subduing the Fox Pokémon. Both Red and Blue threw their Poké Balls simultaneously at the wild, and although Red's Ball hit it first, Blue claimed it for himself under the excuse that his Pokémon had been the one weakening it. Afterwards, Red and Blue returned their own Pokémon to each other.